gout 以 allopurinol 治療，會產生 xanthinuria 因而 renal failure 嗎？

楊宗翰說

14 years ago

latest #16

楊宗翰說

14 years ago

PubMed: gout xanthinuria allopurinol

楊宗翰說

14 years ago

只有 3 篇 1970s 的文獻

楊宗翰說

14 years ago

PubMed: gout* xanthin* allopurinol

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TSUBASA 說

14 years ago

不過我用心裡也是會有疙瘩

楊宗翰說

14 years ago

有 231 篇，大部分都是介紹新藥 febuxostat

楊宗翰說

14 years ago

PubMed: iatrogenic Xanthinuria

楊宗翰說

14 years ago

就算是 allopurinol xanthinuria 也只有 33 篇不是很相關的文獻…

楊宗翰說

14 years ago

為何腎臟科醫師對 longstanding severe tophaceous gout w CRF (ESR 25-30) 以 allopurinol 治療有這些疑慮呢…

楊宗翰說

14 years ago

不過風濕科看到的是不治療 tophaceous gout 最後腎臟壞了去洗腎的比規則治療去洗腎的多…可能有個人的 selection bias

楊宗翰說

14 years ago

但很嚴重的 tophaceous gout 要說服病人讓他願意接受規則治療控制尿酸實在是不容易啊…

楊宗翰說

14 years ago

我比較怕 SJS 而不擔心 xanthinuria

楊宗翰說

14 years ago

Lesch-Nyhan syndrome or partial HGPRT deficiency may develop xanthine nephropathy, ARF, & stones following treatment with allopurinol.

楊宗翰說

14 years ago

Acute renal failure due to bilateral xanthine urolithiasis in a boy with Lesch-Nyhan syndrome. Pediatr Nephrol. Jul 2006;21(7):1045-7.

楊宗翰說

14 years ago

PMID:16773422

楊宗翰說

14 years ago

A few incidents of xanthine nephropathy and renal failure have been reported in patients

楊宗翰說

14 years ago

treated with allopurinol during chemotherapy for malignancy.