seriously theyve had a kid together and in the reboot they have a bunch of romantic implications + they literally elope + pinky literally kisses brain on the cheek and brain gets all sappy + brain considers dating pinky while they are embracing
but in the original animaniacs and the reboot they have implications (although in the reboot its WAAAAY more obvious like they arent bothering to hide it anymore)
but specifically pinky and the brain thats the domain i center myself in like ive rewatched the reboot and the original so many times... i just skip to the pinky and the brain segments now. ++ i just watch pinky and the brain